Changes

Overview

The changes feed records movement in company pipelines as Pav detects it: a program appears, a program disappears, or a program’s phase changes. Each event names the company, drug and indication, the phase before and after, and when Pav detected it. Poll the feed instead of diffing pipeline snapshots yourself. Questions this dataset answers:

Which programs moved phase this week?
What did a company add to or drop from its pipeline since a given date?
Which programs entered Phase 1 across the industry this month?

Coverage

Scope	Order	Retractions
Programs of every tracked company	Newest first by `detected_at`	Retracted events are hidden unless `include_invalidated=true`

Key fields

Field	Description
`id`	Change event id.
`company_id`, `company`, `short_name`	The company whose pipeline changed.
`drug`, `indication`, `territory`	The program that changed, as published.
`change_type`	`insert` (program added), `delete` (program removed), `update` (phase changed).
`prev_phase`, `new_phase`	Phase before and after, as published. `insert` has only `new_phase`; `delete` has only `prev_phase`.
`detected_at`	When Pav detected the change (UTC).
`invalidated_at`, `invalidation_reason`	Set when a change was later retracted, for example because a removed program reappeared. Returned only with `include_invalidated=true`.

Endpoints

Endpoint	Use
`GET /v1/changes`	The feed across all companies.
`GET /v1/companies/{company_id}/changes`	One company’s feed.

Filters

Parameter	Matches	Example
`change_type`	`insert`, `update`, `delete`. Repeatable.	`update`
`company_id`	Companies (on `/v1/changes`). Repeatable.	`218`
`since`	Changes detected at or after this ISO 8601 timestamp.	`2026-09-01T00:00:00Z`
`include_invalidated`	Include retracted changes.	`true`
`cursor`	Opaque cursor from the previous response’s `next_cursor`.
`limit`	Page size (1–5000, default 50).	`100`

Page with cursor, not offset. The cursor stays correct while new events arrive. See Pagination.

Latest phase changes

curl -G https://api.pav.bio/v1/changes \
  -H "Authorization: Bearer $PAV_API_KEY" \
  --data-urlencode "change_type=update" \
  --data-urlencode "limit=3"

import os
import requests

resp = requests.get(
    "https://api.pav.bio/v1/changes",
    headers={"Authorization": f"Bearer {os.environ['PAV_API_KEY']}"},
    params={"change_type": "update", "limit": 3},
)
resp.raise_for_status()
for c in resp.json()["data"]:
    print(c["detected_at"][:10], "|", c["company"], "|", c["drug"], "|", c.get("prev_phase", "-"), "->", c.get("new_phase", "-"))

const params = new URLSearchParams({ change_type: "update", limit: "3" });
const resp = await fetch(`https://api.pav.bio/v1/changes?${params}`, {
  headers: { Authorization: `Bearer ${process.env.PAV_API_KEY}` },
});
const { data } = await resp.json();
for (const c of data) {
  console.log(c.detected_at.slice(0, 10), "|", c.company, "|", c.drug, "|", c.prev_phase ?? "-", "->", c.new_phase ?? "-");
}

Example response (trimmed)

{
  "data": [
    {
      "id": 20126,
      "company_id": 804,
      "company": "Ona Therapeutics",
      "drug": "ONA-389",
      "indication": "Prevalent solid tumors",
      "change_type": "update",
      "prev_phase": "Preclinical",
      "new_phase": "Clinical",
      "detected_at": "2026-09-28T06:18:11.815077Z"
    },
    {
      "id": 20122,
      "company_id": 809,
      "company": "Elicio Therapeutics",
      "drug": "ELI-008",
      "indication": "GI tumors",
      "change_type": "update",
      "prev_phase": "Preclinical",
      "new_phase": "Phase 1",
      "detected_at": "2026-09-28T06:18:11.815077Z"
    }
  ],
  "pagination": { "limit": 3, "offset": 0 },
  "next_cursor": "<opaque cursor>"
}

One company since a date

curl -G https://api.pav.bio/v1/companies/218/changes \
  -H "Authorization: Bearer $PAV_API_KEY" \
  --data-urlencode "since=2026-06-01T00:00:00Z" \
  --data-urlencode "limit=3"

import os
import requests

resp = requests.get(
    "https://api.pav.bio/v1/companies/218/changes",
    headers={"Authorization": f"Bearer {os.environ['PAV_API_KEY']}"},
    params={"since": "2026-06-01T00:00:00Z", "limit": 3},
)
resp.raise_for_status()
for c in resp.json()["data"]:
    print(c["change_type"], "|", c["drug"], "|", c.get("indication", ""), "|", c.get("prev_phase", "-"), "->", c.get("new_phase", "-"))

const params = new URLSearchParams({ since: "2026-06-01T00:00:00Z", limit: "3" });
const resp = await fetch(`https://api.pav.bio/v1/companies/218/changes?${params}`, {
  headers: { Authorization: `Bearer ${process.env.PAV_API_KEY}` },
});
const { data } = await resp.json();
for (const c of data) console.log(c.change_type, "|", c.drug, "|", c.indication, "|", c.prev_phase ?? "-", "->", c.new_phase ?? "-");

Example response (trimmed)

{
  "data": [
    {
      "id": 12363,
      "company_id": 218,
      "company": "Eli Lilly",
      "drug": "Orforglipron",
      "indication": "Obesity",
      "change_type": "delete",
      "prev_phase": "Regulatory Approval Achieved",
      "detected_at": "2026-08-05T17:11:13.732374Z"
    }
  ],
  "pagination": { "limit": 3, "offset": 0 },
  "next_cursor": "<opaque cursor>"
}

A delete means the program no longer appears in the company’s published pipeline. It can reflect a discontinuation, an approval moving the asset off the pipeline page, or a relabeling that pairs with an insert under a new name. Read delete and insert events for the same company together.

Track pipeline changes guide
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Latest phase changes

One company since a date

​Overview

​Coverage

​Key fields

​Endpoints

​Filters

​Latest phase changes

​One company since a date

​Related

Overview

Coverage

Key fields

Endpoints

Filters

Latest phase changes

One company since a date

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